ࡱ> q` bjbjqPqP ?:::< D.2ZZZZZ555T.V.V.V.V.V.V.$0ho2z.55z.ZZ.ZZT.T.*|\,ZN pcü~`+-.0.r+33$\,\,83,50e"K555z.z.555.d JJ   Organized by the European Union project RIGHT (6th framework) and by the Nucleic Acid Center, a research center founded by the Danish National Research Foundation Perspectives on Nucleic Acid Chemistry for Therapy June 17-20, 2008 Sesimbra, Portugal Tuesday, June 17, 2008 Arrival day Registration Wednesday, June 18, 2008 9.00 12.30 Theme 1 Do we need new methods for oligonucleotide synthesis? Chair: C. Reese Discussion: After more than 50 years of research, it remains difficult to produce large amounts of oligonucleotides (especially RNA) in high yield and purity. What is the reason for this and how may progress be made? Is it possible to develop methods to synthesize longer oligonucleotides and to synthesize them faster? Lecturers: W. Pleiderer: Oligonucleotide synthesis on a chip. S. Beaucage: Challenges in the solid-phase synthesis of RNA oligonucleotides. J.-J. Vasseur: Alternatives to solid-phase synthesis of oligonucleotides. M. Damha: The adventures in DNA/RNA synthesis. 14.30 18.00 Theme 2 Do we need new chemical modifications to make nucleic acids therapy a reality? Chair: J. Wengel Discussion: Oligonucleotides have been designed with modifications in the backbone, the sugar part and the base moiety, with the idea to increase thermal stability and protect them against enzymatic degradation (playing around with conformational restriction, base pairing strength, charge neutralization, stacking interactions). What are the main properties needed to use modified oligonucleotides in biology? Are we still missing something to move modified oligonucleotides in therapy? Which new oligomers should be designed? Lecturers: M. Damha: Decorating RNA through novel conjugation chemistry. J.M. Escudier: Constrained nucleic acids: synthesis and first evaluation. F. Seela: Base-modified nucleic acids, synthesis, molecular recognition and application. Thursday, June 19, 2008 9.00 12.30 Theme 3 Conjugate chemistry versus formulations: what is the best way for nucleic acids delivery? Chair: P. Herdewijn Discussion: Oligonucleotides need to enter the target cell and their intracellular target in sufficient amounts. Despite some success in vitro, the parallel in vivo data are lacking. What could be the best delivery approach for pharmacokinetics, cellular uptake and cellular targeting? Will it be possible to escape from the approach of local delivery? Is peroral delivery a way to go or are we happy with IV administration, like done with antibodies? Lecturers: M. Gait: Peptide conjugates of DNA for cell delivery and biological activity. H. Loennberg: Glycoconjugates of oligonucleotides M. Antopolsky: Peptide-Oligonucleotide Conjugates. Chemical ways of preparation, investigations on Tat-related optimal sequence, studies on hybrid molecules design. 14.30 18.00 Theme 4 Oligonucleotide-based drug development strategies: which way to go? Chair: J. Engels Discussion: Many approaches are available to intervene with gene expression using oligonucleotides. Some of them are rather artificial (antisense, aptamers), others make use of natural mechanisms (siRNA, ribozymes, CpG). What are the most powerful approaches? Which one is the easiest to develop? What are the pitfalls and promises? Can we design other principles? Lecturers: E. Uhlman: Nucleic acids as key regulators of innate and adaptive immunity. K. Fluiter: Testing oligonucleotide chemistry in vivo: Considerations for preclinical development. G. Sczakiel: Intracellular transport of siRNA and RNA interference. Friday, June 20, 2008 9.00 12.30 Theme 5 Biophysical and biochemical studies of nucleic acids: which information is needed to improve our understanding of the biology of nucleic acids? Chair: J. Chattopadhyaya Discussion: Plenty of biophysical and biochemical techniques are available to analyze structure and function of nucleic acids. Which information do we need to answer questions in biology, i.e. siRNA? How can we generate this information and make this transfer of knowledge more successful? What are the key biophysical and biochemical experiments that need to be done to better understand this biology? Lecturers: D. Patel: Small RNAs: mediators of gene regulation, catalysis and silencing. M. Sattler: Structural biology of RNA structure and molecular recognition in the regulation of gene expression. O. Plashkevych: In silico elucidation of the cleavage mechanism by RNA cleaving 10-23 DNAzyme.     ! - . < > ? W Y Z p źثxtp[xWRM hw5 he 5he )hUithW5B*fH phq h%HhL{hWhW5B*phh5X1hW5B*phhr_|hW hUith5X15B* CJ aJ phhUith5X1B* CJaJphhUithUitCJaJh5X1CJaJhUith5X1CJaJ hp:h5X1h5X1jhp:h5X1U h5X15jhp:h5X15U    $$Ifa$gdUitgdUit)$$d  %d  &d  'd  N O P Q a$gdUit&$d  %d  &d  'd  N O P Q gdUit$,]^,a$gd5X1 !gd5X1 ! " = > ? X $ p$-D IfM a$gd%H pgd%HgdUitVkd$$Ifl4""   t 644 l` ap X Y Z  : iR & F ld^`gdu@$ lld^l`a$gdL{ ld^`gdL{ pdgd%H pgd%HVkd~$$Ifl4""   t 644 l` ap  X      8 9 : H    ȼȡytmee^ hKh$hKhu@6 hu@hK hP6 hu@hu@CJOJQJ^JaJ#hu@hK6CJOJQJ^JaJ hu@6hKhK6hKmH sH h-k^hKmH sH h-k^hK5mH sH  hK6hwh-k^he 6mH sH  he 6he he he 5 he he he 5 hW5":   k l ~ +{ll & F ldgdL{$ lkd^k`a$gdL{ ld^`gdL{ ld8gdM ldgdL{$ lld^l`a$gdL{ & F ld^`gdu@ & Fd^`gdu@    k l m r s t ~  )*4:;ݻ䲦zumeumezeumhQhQ6hQhK6 hu@6 hQ6hKhK6hKmH sH h$hKmH sH h$hK5mH sH hKhK5mH sH hM5mH sH  hK6hr_|h$h$6mH sH  h$6he h$5 he h$hMhM5CJ aJ h$5h$ hKhr_|%+(znbN ld^`gdL{ ld8gdM ldgdL{Vkd+$$Ifl4""   t 644 l` ap $d$-D IfM a$gdL{dgdL{ & F ldgdL{()3wsoc^VhMhQ5 hM6hMhM5CJ aJ h$h{Yhr_|hr_|6mH sH  hr_|6he hr_|5 he hr_|hMhr_|5CJ aJ hL{hr_|5CJaJ hx5 hr_|5hr_|hL{hWhL{5B*ph)hUithL{5B*fH phq #hL{5B*fH phq h\6hL{CJaJ(J|!"~ W & F ldgdL{ ldgdL{ & Fd^`gdM & F ld^`gdM ld^`gdL{ ld8gdM$ lld^l`a$gdL{HIJOPX{|!"9ȶȤ|f|_[VOGO[B:hlLhlL6 hlL6he hlL5 he hlL hlL5hlL hq h{Y+h\6hQ6CJOJQJ^JaJmH sH +h\6h\66CJOJQJ^JaJmH sH #h\6h\66CJOJQJ^JaJ#h\6hq 6CJOJQJ^JaJ#h\6h]6CJOJQJ^JaJ#h\6hQ6CJOJQJ^JaJh\6hQ^JaJh\6hu@6aJh\6hQ6aJ hMhQ   UVWac -ǽ¥zzmhaYaT h{Y6he h{Y5 he h{Y h{Y5hWhL{5B*ph)hUithL{5B*fH phq #hL{5B*fH phq hL{h{YhPhlL6h~h~hlL6 hM6 hu@6huhlL6hlLmHsHh{YhlLmHsHh{YhlL5mHsH hlL6hlLhe hlL5n{}}iRi$ lld^l`a$gdL{ ld^`gdL{ ldgdL{Vkd$$Ifl4""   t 644 l` ap $d$-D IfM a$gdRdgdL{ mnoxz{6789:FH۾۶۶ h;6h;h;6 h_e6 hu@6hu h{Yhuh{Yhu5 hu6 hr_|h{Yh?fh{Yhe h{Y5h{Yh{Y6{8 & F ldgd; & F ldgdL{=0&P1/R :pL{/ =!"#S$S% Dd7=R  C .Aright_logoR5| aDF5| aJFIF,,CCb2" }!1AQa"q2#BR$3br %&'()*456789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz w!1AQaq"2B #3Rbr $4%&'()*56789:CDEFGHIJSTUVWXYZcdefghijstuvwxyz ?((((((((((((((((((((u)!"  1/o|SuO?wW}oh8 W8 W딢:NoC.NoC.J(8 W8 W딢:NoC.NoC.J(8 WC,?hOvw'kw76(& ,\R(eVԀM?dO8߅.@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@uO?wW}ok?׍_yEQEQEQEW'o ^SN7o?˩AEPEPEPEPEPEPEPEPEPExgÏzSk}hvOh}cj6 _[œ4Bu''hsF1M$إ(9JJ1JRi$;z+ {}o_B]}>+S9-Oމ= 2A 5Ωom0$g7)`m/_7˴'ɻ𷄼)L@&_8*'b6pfj2uRjQ}c_4Sb8$Wp1BEN-_Ƈ5bFOx`rдO6ʌuy~߳n"6>%xHwXv FW寪x'&!'<Ni'g415ӊ~GWxnj8ʕX\Mu)O?+u9 W6i@IUҾjSo;o.q95wqB5[8D~4{3F;>?x\L_T_IxGh=5ׁWO^g >>ic_ b_o&>hƟUX1g]?5?>Zc8q,v>TGDL|K1lI+49{ sg> @j {& {`q^:]_W.xc't]6_7d y-_xnɫeK1qo诽Xx6麳?+rѡ;w+ |QA)O xBO8޳ck Um o:K~@y+x' NYXqA ) v_a/Ai /2`(^ ҼJI$)J\l9O0)ʓcùSn\YnuIiuGnr[K `IІ&ٹ8gQLXPH#FAI#O= (((((((((((((((((((((((((((((((((((((((((a_?noڟW?{~3x>巄~^[I ֧B;x"ywqpdۚB:*+7yk25ϳY]̩R!R<~NQ!R1+qNٟͫ/3bqY)T)GT|9E'fںN=[W [W :+N%s yg2mg?6O~o_C' ~o_C' $N%s yg2sCl _lV|U?`V|U?`N?[?ǖ(mg?6O~o_C' ~o_C' $N%s yg2sCl _lV|U?`V|U?`N?[?ǖ(mg?6O~o_C' ~o_C' $N%s yg2sCl _lV|U?`V|U?`N?[?ǖ(mg?6O~o_C' ~o_C' $N%s yg2sCl _lV|U?`V|U?`N?[?ǖ(mg?6O//wOǑ[c~|{瓨|3''ӥz*ދ2˩|wHͶg5/1\t~QXn p۾9.] | ş)?6χ.|ڦ$Ybݱ\$ُuɳ'IK+,>ăgOkWϵU,8*790_O?$Ӽ7R@7YK۟ ͛>|Ѱ(x5C.y2ܱx洡^$1ݳ[<(s-sgtWaiQ)?N\ҥUaQͭ\E2 #+B(((( :uy+_75Pj I}h(((+N7o?˩'We ((((((nơeiZmڎ]AcaaekMswyyr[Z,"EHHHi6II%v$Mdmv^$@'~&?w;?f_ [گu#UJO_E=Ĺmu5ݮRhǁi(O~[(>_/~|9O_d%Zk4DwKMwėz4+mY$_#TȲIbU:uAޡMJ5wf|kƹ.XN^?=T.1 (TYū8#?|wZA/ÿ \OψKrS-Âx4k;Fz=G3ꪞbX㶼mHEFrM:Kg |YeYydvgy$vwwbK33I$I''e~ZLX๗ZxL$Rx0"Rw_jQ:T3[ q[ohknwEς}(,VBw%tXϏ]Uw/Jf凌FSqO;>̂?֍4i)Q_1_ qf|-Ԛi~}qcY+k ;澧bhjGRUpzh;ii^5U&ʿ݄'ְ< G[CX殏y'/ć]|UEY' 7a?H}A)ɟj?|$?ŏjBkHTQЛ*vš< G[CX殏y'/ć]|UEY' 7a?H}A)ɟj?|$?ŏjBkHTQЛ*všn7_C>":h??[ZR=WAC{ gjuk( ,?>(__>0>.)|-9prN%7fs)FrqbڊWG֭_(ʵZ*R9Tp9һn׵}B(O ( ( ( (?O9? ;浮|d4kVaRմȼ]ŧjWԴˋ(.RI!YeT$?[aju*WVW +-bkKU֫%ueT)5ICx\C,N" +PZ"ڌdmWI !,WG< G[CX殾*V?M O;qS[>BkH$? $6U')753_y'/ć]O(_/oc?Oe_n;qS[>BkH$? $6U')753_y'/ć]Ul71E^#`h<-|PREu{ߊ ɢ}[SM2MI4=oBkch'.- ?#q ]]r7E_ez8VRl.jSǚ]dѴ}/1ux-LV"%,O4'^+`-^2N&i=E8~Fot9մQ]Bѯ.-g@ZI:2=yŏ%?Cw5 ւNiզj8z4芍si٨INSΥTax @>x \eѯG?26l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿OՏ}C ǟO=>}C ǟO=>)QO&8{ o3qC\ _XT?ycT?yc?c˖0l5̿O3^Ok|Ez?Zơ.ᤖT4Rw(K3BTXFDԫ2C)#5VW3.RW0vhZխ#|T$HmPQEQEQEQE ~ V][P)báj#8ѝ𪤓_5og#~+=׊qO$>ө*9uۘ@i jr)#(((((Zy|/~ |ENxOL|Ijv>閫{CQkhW*d4pY8$k? 3]ǹcI`Ze ;χ_1b|q aҔV72sCEV֞gZ,iԏ~GC*i5;Jv7J0O7Gk5 F?Sg Oց ›^+X ;`5uoMxeP`?ଟ/^ZVY>uǴݲ[me%ñ<:EbO͋˽Byn.yY.'YWi%Gi$݋1&b_|3Хg1I6ӌN}~ntQN&x~1qfiJtG7h(I?Qrʻ}Ti&8YEWg˅Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@o&~HRþ`zWĈ;W9ͯ~<-fy#I7ŏ݌c/a&H"NlЅxJ _x ?T}߇ڳG/NrM+((+k (?xFZW-~m`_/J8cJ^Ss5^e`G%Q_!QEQEQEQE~,?>(__;C]!ʿ5?gD\ QE)QEQEQEQEl?=sPMNJ6ه˞&_¥rx&,Sqx (\>8(((+IhK._؏O#G`/?_v2M+Z}GM8O+0 K~$؇0j?H`+l?KK?SY3ͧ/.FۓMs%~"~ O]_P}_⷏ºt'ID?x4$h/Q#~J Y1篃RU%pg)GԌ&=yZ4|p$LH rPy((-xYUDmM+X8bַJhѐڵţ8@}2[Ug~$) Fִ FKm$%Ŭigöy[]QA-2@ɤ^wA.ZL1@Q@Q@SYQ݂,p@$4?ύ OY2>-r]X$]ީ+EٕrnrUcgiVVPZZĐ[ (Ɗ(P]/Z|k

!nº:k$$H6;٬/;K)_(<y.o+x@ևNѴr%5fx ]*wo_. / -Z]>UO5ko?E,BK-7NK- OtoӼ6XR0U" |ci՝rN3-:<-)*:4k|q- مx÷j{4J.1MJZJsPடࣾ9nnu?GEͬKO|B1OWѼ3at]WWֿ$(2-Ȳ>”)8ң6U*uմZ%*&ܧ)73Ӱ+˿hܹ1ܷ$Ϸ0ϷϷϷϷϷϷϷϷϷϷϷ%-*|+Ĵѳng'<`s/N>b ΋Q+wd ,; D"וW%qWKɼ/S?M_EQ_Q@Q@Q@Q@W}&0s?Taju*W'n >GGO1+り(((4Fۏ_4~k//2]p___?(?$G~.^^cIoď] BPԿSu?/%7F&[/tuAEPEPEPEPEPEPEPEPEPEPEPEPEPEP9ɾ| ?P?g/7ρGQ_8gb?zD娢U?U *+7ykT?[oYiu?[tEWQEQEQEQEQEQEQEQEQEQEQEQEQER*C r)( 0wOߏuSS7';FI|_K+}_Pi5J-$+v#A.U+Q~?OS?f]B:|d͜W^|R,Ԑu/(Jm6 Xjk3 qyтXbGTJԩS m]8_0gq5%Z4zW'I_ީƫQEgQ@Q@Z扦xF:' J|%ox{Qp5_^<ނLg|#\Z)1+go-_xCinK=TKh(,KiZ+j2!0H=G(+cg,?֞o>\ݢMmo>c Ŧ]4'jak:kֱnX"(Sqy I40 /|;tfZu[Mkw@KjrH,#3[mh`((((+3Zִ |Akֱ]AcZVm-/3\]\I6E$ƌN9c c/8|Fx6!i7[.4 ~4 ϊhdדĸCb-PQkΕ$&yykC&5F*uJzY4%8mZ,GTA /<_鿲-cQ_|oDe"qCV%~@-}gĆ>+2\OX| N*s+֚KWQʭj^u%'d;quzrEmA}B)F[E-QE꜁EPEPEPEPEPE_ںx῀e^C k^)՝+.Y_]|$A3 PJ:pW%E-ܥ&Ce9(.RSroJ$qTW/"ß kk|'X"lfi%k 8lu  ~ : \+J%]aA 2UR[\I*5(8jcnBZ~N)C )JU^xjH-ycϢ= =-ot¾5NsZŐ'/+ gkե)E4}2+8Š(z%lj|SZd[7qPϙ:w(+,-bWWX[#?P?/.$TOKIg_I]B5GQEQEQEQEQEQEQEQEQEQEQEQEQEQEe~_o57FM_WN;aX=3:^?j(OBʳ )) ZU:*+7yk%bZ@ď/G~yQEt~:QEQEQE>zt? x6QW|I5׼Cs½W[u_ំo]cX/+=jw]]5IJM#}9{ь?#Lg4VSN6γ湜cfqs jV?KU$d%ZҸ< 005mJ7mjTM'o ~[wMN9¹MC Qԃ ؛pq dt+B oc#}+#w%`prQ^.FUګkW׃\'|WH\0~!LƏ6]<$/9Kڃuy7yf~%ymaɛPHt6$I5x[DEaPCPB=A }K峄s ,S3 O 侪'=myG")<,ӵ;+Iܯ>ڰb󭲵՞+-ON:R85<iʱ3Bj>V*1aڃBtQ)s_; Yƾh&)$߳wJrn,|.(O ( ( ( (?g????5#o ɢ@GF|Si.WbWA2п? HW?|?hoY;LlRAW?CcO2ldUJ~o 5'ˈQ]<8chU,{|Z^߫aEW QEQEP@ #zE#f ?&MhO|tZΈ!mք@Hdt-sH?_-w+ ZSA!F<}Uf EV6_+Vҵ TtmZk SIӵ+=ouo2sHfq)#Ϣ 5Od}NA-Ɉnlب  3Ɇwyp.o<|p0FJ5`<_ZW4M+úV>i#Y۵.ݬh;]ϷϷϷϷ>?ϋwD73Ӫ-ǎuoOY\ڳ4n<|)o?|mg.G֮(((((V67宝Z\X%̋ *Oq<ΑC HK#"0|q;.SҼ>|*F "&ݏ>XRk*7->"Lg:Q>+8<.^zgSMJ^[cjWaZj^*QjYZ֎|ҳP4U3/t|%>%xWroWRYct{[@=F[cѧ!ӼMOx?VEN(K5KO xp\V{jz1d @ڟσS߳/ |6Ҥu6ͯ)Я˾ѼEXkZU`Z~osip$m'+~P%(-8-QkTViNM&i4՚j=? h!WC[C~HW_odcum$2M4ws;$i/Jdē ?ڷ aȵ_~<;Jfy&<ӴC%ׂ1^&ۍ/NacW3ڿƿS=7#o/4M|dռI/h׺&,M`%Iisi9ɸGXeVF⼢JBt }kMJqeJE(i;*YF2SURM&{4(((ͯ,+%?i_e~DG-+)x{ǙO Eyc?XQE0QEQEQEQEC]WR#cuUs*o <Ïc?gWQpEW!EPEPEPEP_ɰ?\A5:+f.z 3_O~QL@(pࢊ(((G '/_ub?i??6K Wyi%6W,WO>(+ ~'׈|74k4MWE4Y$THتij@$ݢd(.ҋRӺz]Dii@ivokcs3c8'0S_?wxc h.E6#a>kNh?Ŀ6悏Ŀ6悿(7؏"?]?M~ |Kmh(M~ |Kmh+ᢏ#M,CNh?Ŀ6悏Ŀ6悿(7؏"?]?M~ |Kmh+s PGGÿߊ76gF}^*!ӵ;fI|;x3̒ %.u?O9'UoK㌸,̳ج3bpV>W:8Ju#F.^\/`\KF=*&N為J/Fֱ{?z(Š((((_#?Si~+xd? -oYx{o%i\ŨXv`$M#H2POWBkg_o A_1Yk& ' o⧈|emey>ġG.,<0 ejZ|-Z76vVVG'y&cqx+*OQECV\B*ъZE^wwg=QWE~wwo)E w ЮA&%4&%4pGEW!p _4Bkg_o AGBkg_o A_ ]lGew ЮA&%4&%4pGEW!p _4>6>_5ʷ𲵅<=X/Hbԝ"-i"GdGr@4W.%9ԞiRS9a&'eI]IvG,TcQJ){J$: +OL+?[SJmo8??wQg%|Hn_azQ_GEPEPEPJG:JU>~c?u|ɌƟj߳ uhg6?cԚ `?(8 ( ( aثE.hx$~κQS}^2֭w$E"1tgK2J5w,=W'l~)~OB5~Ͽ4Hm6tЂ ~⾟3=9kBr <1 -W^hc(ƮH,f4QxyUTTt_jqu(y¬c.I?VYGqI_QEQEQEQE}_4q(0䫕#"zUQK?&~urKA$0i2ocu%"E|9KC+Tk1j1)}Ee>Ҋ-Q_g!EPVy6kC=yC-GARWz 0$d:~?mX>^6b '|+ ~%->)۱K#rIyï‚OձG.xI5}zQ__E(M!Xn>=|]7ƻ7[ٰ3~&K(mV*ӭ"[]:rnEc›0+p~JmJ7gkN5,e ~K&j}R8I8N?fqYj?Z 'Ʊ@Kmacz۪$z>B5v/9?´/<-?VFqBpc09 ]ZL#]C F+:׭~?V8O~OvGI6|RSS. ɦ7[ xŧ½F WW,|In|)km%&{2-o.+Q_PE/xz͇<#V?RuӴ]BSKۈm,,-(H9?c.YSX-c&|bc ux~Mc 5cx%h -ocHu+ :,ק?QD-?k)5Ĵ.ٿն"+:o?<:ǀx N'0ȳJ-] ZaN5"' ) J>LTӈx)b'J:tfխK 7iRJMTeVrJ,QJ(Š(O ?+|r(ޯHO{o"RM.ɤʶOZfES? c/Z%-]j(#8ZgvDna}rHu;g+:pG>%\$?!ӽΞjmG㖱ܲ'**Ҵ(JG_ů+Go>6?U?7oRFhӓG}GB!k0rQ> Ϭ;6i߅o"ɛw|>֢K7(]]_K~8h6l˨xY2IuF#Auv7 skޖQM]Q%eh 5Xnbӵ]#TNԬ.gxnmn!wx%Xّ _ u?k⎻|B)Knsu_Ot}hd|8.K|!~YXZ/&_GǞ oˡ 6qGޭrWu'O R2<){+%Ա2\"שE6^+ EbNUꪊ(j"Ƌ$D*(yg`wsC'ɧE?]&~WQ[~'~mπNhQasi~972`hȾ9_xbr'%56KN%`' ˍFNk٭l=;>U+$Fq6,O0豹ɭ$ޤڍ6Ө3N֦~%Uo۷*ͨ/;˳ŧ:$ھej/Ju"~)׹Cۼ<7RJT)ӥO,B8F)F0bQI+#r')Nss۔,U9JRoW)6oVlQJ(3T(+O /Eu?7oΟ%c}Z>)0kJYkVRWv1m"(=((((((((((((ͯ,+%?i_e~DG-+)x{ǙO Eyc?XQE0QEQEQEQEC]WR#cuUs*o <Ïc?gWQpEW!EPEPEPEP_ɰ?\A5:+f.z 3_O~QL@(pࢊ(((G '/_ub?i??6K Wyi%6W,WO>((((((+wϾ?&˿&ε[28<-cϞ'soܔ(x ( ( ( (?/4K/d!4K/d!m>S!5KQE~N}pQEQEQEQEQEWVY%?;__Yfp-C}KOS"ܿå*(B(((zt}G?cO5oU?:3?տgT?m5OQ^qQER3*@h(OY)OeFe/Dע&0]m|dּcsm$Z#C,\`8¼0 &'0Jq5J'7j0uqPeRHSb(63~kj'mp(iZo| .`˚i[l[Ůzv7ٵ _ÿx{_ ?`xV:siz (|dtQs<3qt~-׵ [idÞc-?GQu]VR+CPgy'I&Gi]٘NG6eT8W K*8 ౸4}9y7]VjXtaqaXjVUSBK7‹i:KT_p\sS:(OŠ(((+O'}~߶MxsZb&khN/ԑj^4ZAKK9M1X.3@y16Y8ڪՕ 4)ʥIj,_,wFzqUEεzJ+Nbڻވ?Oيpp65;?|wc2Q,Ӵ:Eǀt?ېks^_t}3ú>h6^:FBz~Egcciac$#5E+N7gYsc FIJ.J0-p*z B)Jor ((Y"?Y?6;g$I]dڿ"s><9"qh/_OD5ciU-c-m{VH^9'?߄yXk~xRʱ }OUn\o*iJF,DqF2|T!::pTaB.Sc&)Im${c)59JRiF1JI-[z%?Qee x[?7o#ᱳ٪xC8|o)2m6xn2J,ִB.mN8͍wٝݙؖff$3I$I$y5gX|B5%[?/%  <54i$ǩhx%.= 3mdž z|ÓVryGX5%{җI7 W",>Ny,3XIO CRtԽty.wt"+:oοS?E'%xUؓm4+?Š(IĨ~m\>ׅvAXlB_ij=X~B_ ZS"o>O(HmIǗ0r |u>L o5y*<-f ZxTSj8,&߲/&suTR((((+ae~Ǟ-u(ASWö.=E%pyDko|;_xCYg ӚVw6`Kk;YZtז5J` K GSӟƿ:^8~+G<ΰ[6YK/t*be9Sc1N*)R#ikI%3Ը[ < LK!NIEJ\.iҽm.׳̏z'GOƿOsKsKϿ\qUa?[Mo+(?׳̏z'GOƿOsKsK%EV U?%S[ #}/G=_~5/(~5/(qUUonx¸{<K4yDk?i8tq??i8tq?\qUa?["^5^2?d?!?iG_/iG_/wXO5VMo+(?:ѿf/و+)?2&kVAů-,<+7k/x$x-sioj[4L4ТHcfBIN .CW |u^&P':*UiOw{_K3hY\eJt`Jj^ʚ|1NڅQ_bxEPEPEP_؏O#G`/?_v?n?|m_8/JlXAğ}Q_QEQEQEQEQEWYɓVL":L'e}px[/Q=N )=Q_ QEQEQEQE\_i_ɯ_IC_?i_ɯ_IC_ '9|UxCk_1X(ࢊ(((((Jmo8??wNʳ )) Z:EؖP?9#EKQTQE]Q@Q@Q@PC{OOZ]M lxX74 jVCmqS[$$;>e|jCc?䆊׫V^έjRo*$95jn$HHqӄa Τa^ 7Ij?쏍A#|-N//JꋤDO"kj7g~̟ms~۬xyƟ)kL|%pKHo8UR/ʂ?_AυUJj%€yYtI d|eTU:oƿ xddOdQ ^' ld,,\Ê+xsF.d֩0ToŪ5^%&z?g^T!Wş(?i7dM/—I=M ,œW$if$v,ĞI%$E}^S8KOa0p{a+W=zkTISQEuQ@Q@Q@Qץ9eDRUA,@I-w_Wq⾂oDi^iڍSw"o'ic~am2v-PEuQy14@"k7[G\Zx]'Ŵ|Q"̉}20-RSƾӗş *x5j䘅V*{+­j3槖R_,FU\dӯNײ~5::IAJm,TAQO]uQE~QEQEs,[ğq_?묟WEoW}$m__F?ő~YOMQE<~Z^=GDԴgH5]&R5+ m/Bt{k[IaH]AzPO 6֯ƿ-&#SHl&E :)dcmvGx+8nTF+XkN _Kv3;`q1IvX)>w>SFOmfiONWGtcrѱ+&*Yv"l ti,ֺj?۳s>:/Э[o>'sm̹֟ᬼ+kѳ0C%črĞ;Ƴ*ǵ[뷱ZճPٟ6#ٔ]E-U"3ߩaͰϳӰ°X1`_a/jجN*IԾCK^^'U߼)SN+?haEW'Q@Q@$rP?eM;{ !>־tXu'X|:l[.$;vnc[@[5ISc/0\.7PK4sNeXʕXc(.IR>[*աøjTR3rԥ9S.vm;=Si{gWZl~Q՞$Vÿ//{gWZl~Qg??Հp̿c¼G,?DR=_]j?G= WG Gk?՞$VO2; J~?u)_.(Vxs Xg<8+K+֣4?zƿ;hY'O5`??//{gWZl~Qg??Հp̿c¼G,?DR=_]j?G= WG Gk?՞$VO2; Do7M~c⧌-xD5? uyGObwSJ5 Fa(w濡^?2o_s߆UC𧉔(axpj4)f 4Ч T-:tB7m1JRAԫ9ԩ<=:'*+RnM۫l(S ( 2m"^#іK__X/FWdK2ҽy~W3QEWH3Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@b?i?;IhK.^1ɷ_eO)biQEEPEPEPEPEP_˿e&O{I[2]/2sO߉oF|;7QE'QEQEQEQEqYk& ' o@Yk& ' o/olU޸I|]`+s낊(((((ʳ )) ZU:*+7yk%bZ@ď/G~yQEt~:QEQEQEQEQEQEQEQEQEQEQEWU?|>sbaogMSGo5 O󷷑?OC/X 0\_[6!WtBUY _j h`۷q>AT#;py|\NT5|%>|N!ըқ]lg~+3: [+)B Rԫ+R8j=𯉼o^ J|9.Z5NAZt70 kX%W!Q_O _ xg~Z=oٮIm-/L͎xZk ZCk&&Hך}Cֿ:È> a oeDܖ^Qwx?LyC%Bs%_}79[*Zx.NgUfxn(F qS^ߧ/x{(`OJ/O ͅ%uxk'ҋOJp 1[AE 1"QF#8DEQU(w(((Y"?Y?6;g$I]dڿ"s><9"+x(o@_goW>~W1jWlE;N\c;Œƺt_2Q(l& `p]j*NVTKz*MYI5Z"jz5 tI\twwhB1]QEdO~_R/ =~Yg?RH7[$?z9?&QEQE;r4bua'5_Vt'%W׷j_ٚ'g7>?#_ҿ *Z_ y2orl{ęԗ +SŠ((( <ѡ@>s:Ds-ofh%}#zqOiOۚ? | wR)\=Pϸ_6T:e4וK}?zh=Ld]hEWQ@Q@v}-mISc/0q?|5S(]Q_GEPEPEPEPEPEPɓ|zV257LPx'bŸN? *Q_}QEW QhZ2m"^#іp=çSk"1P,J(C(((((((((((((((+IhK._؏O#G`/?_v2M+Z}GM8O+0 ( ( ( ( ( ]/2sO߉DWYɓVLN 5s縯I%3'+?(((( 4_5k?k~ 4_5k?k~g?~M`3RQ_\QEQEQEQEQEUVoIOgNVY%?;_G_(>$ȷ/=Cʊ(Т((((((((((pA?^6'¨|p,W?ox[?{R=W6e^޵ItN~|m់|q|Cw!}x&{YXsgwi %jz 2Ÿ_A?(~^K9~ig<$LgċD 1.YmZ*?x3Ga:p:qsS)>.4ӕPjgccR8S1Z|1j`J4hq*ag&yE%RJniqG)A  QEQEQEQEEoW}$m_wI`_M8Q}0Ef>&7shϷϷϷg?R7g婟Ju"oMs6cԚϷoEl[ɪIG&;70䴅>у7AQ$3W)Ѱî簿2?8$)?Z[O8yQ>K?.(@((((((Sɾ=~W_&MW[ʿz?S?1_@O'rܕ(>(+k (?xFZW-~m`_/J8cJ^Ss5^e`G%Q_!QEQEQEQEQEQEQEQEQEQEQEQEQEQEQE4~kG '/_x&߉->ŊIE@Q@Q@Q@Q@Q@.u?O9'Uo+wi?~&WY'bW$m`EEPEPEPEPe5ԟ5We5ԟ5W𿍿qW?zo&_u(Ϯ ( ( ( ( ( *+7ykT?[oYiu?[tEWQEQEQEQEQEQEQEQEQEQEQES]IVV `r#Sh,>*2ŷ.U;(<1΁K.;y5bw$7qg<~oZZucK-?Ƃo/؅\7z#ėڧ6AmCS^00i<1ڙo*#n h!”yM9sbpꘫգ}[IӨr_ (9>((("?Y?6;$ջڿ"><9"+x(((+3)J_z"+:oI^&9v$re1M#E(7p(N'+ 燛RDSA4wq OsE$l9#C*A  }!Cr|EyPVUUW7{oqtI?de+wVxPQVF-Q_EPEP_ğ%72| _evz|M0twVSN>G^soTcO&e !?Ocg¾ >-s:?_9gAolr淲-wk+$̪Ītںj~֚[3[Q_^xEPEPEP_؏O#G`/?_v?n?|m_8/JlXAğ}Q_QEQEQEQEQEWYɓVL":L'e}px[/Q=N )=Q_ QEQEQEQE\_i_ɯ_IC_?i_ɯ_IC_ '9|UxCk_1X(ࢊ(((((Jmo8??wNʳ )) Z:EؖP?9#EKQTQE]Q@Q@Q@(E%*Qۯ>_?%(+Τº==ʫ\|岵%ma4Ũ߳$10R(ӧㅌa*͉B%*ϧhzޓu-jV7(YC,"GBsU%Fq('FI82MFIm4NM8'E(M;44iQEB ( ( (67-o"|YJFu3a)Jt{u 3Q~hom๷s#EѿmOz%mtRz?&b$ tFM+TEM"3~gD/ؗZ;ƶ|gO؍أl"񦑳{_eɅو!5:)%(.ф%7󰨯KGږᷲUU0欏2(0((?oڰ׼%qW,?>(__?Ho,r&O863uQE~ ~QEQEQEQE)_ue\SR:Ma _ܞɻ?35w%'a?( ( ( ( ?n?|wW#q ]̼coĿwQSe$袊 ?(((((:L'eQ_d?紟U+,1\+w6oL 袊@O瀢((((M?M~O߫M?M~O߫_8?p7X/ԺEWQ@Q@Q@Q@Q@gRSkAӼuUVoIOgN7J,Ĵ:ω-:_P+t((()WIJG:Z#Lg4VSN?`1[}O:ο F٧qT?QE!EP1&0x> kBx^Dz]јt`[k yr&T= _ 5׈<&_NJ]SÞ";tuZMti{[]5VS_Tl/m~7]sZk \=mšqji_><nkJ3*I^Ur(ӞYKVpIZ4<1q!aG?gVY5lA>nMU>+(((+?GOG|oOO(0 kG%K/rU\7u;X>QXpq|FN55pSWZ5*Uiu)FKlU'F:ԤRR$ /8& x[PF~|-Ï/PCdlt{ϊ:/ ‘ÿ [XKP]:ki_utoQX񿅵~3"Ů6_x:{l΍/ZE!&Ce8o_|Σq奞eM?[ATqTʪKVo0/,LUӪֽ 7A+L@(((+> |__5|5՟D/0֠$tkx旨Di#yuwcp ε*XUhV kS*ԪEJ)TJsP$(m29Ӝ*S(jQZeN-&5sqcO}4cE]CPE\x[6xGQt xQf]W֗vI# [/~u+[NNHtFI[i#K?xw0Aoe;|1q%G$sF,RtWFRU A/%ݪ9%qW,?>(__?Ho,r&O863uQE~ ~QEQEQEQE)_ue\SR:Ma _ܞɻ?35w%'a?( ( ( ( ?n?|wW#q ]̼coĿwQSe$袊 ?(((((:L'eQ_d?紟U+,1\+w6oL 袊@O瀢((((M?M~O߫M?M~O߫_8?p7X/ԺEWQ@Q@Q@Q@Q@gRSkAӼuUVoIOgN7J,Ĵ:ω-:_P+t((()WIJG:Z#Lg4VSN?`1[}O:ο F٧qT?QE!EP_CZaM,K٧QK/Km_M?QYf>T>h0i>د#\7~ǟ o&ok?oŗRyMwm94*̌RH9IP~ԫ`~@j1x DK^z¾ cLjNlQ$Xͳ`.}!qFy?Чoi͓q9}IYnt9t_Ho3&jK7 ib"KEuI[v~QE~QEQEs,[ğq_?묟WEoW}$m__F?ő~YOMQE<~ZQEQEQEO~_R/ =~Yg?RH7[$?z9?&QEQEWkU?㿀0~:N>1|6(|huӴ؀&MG>$}w.3_tUud` *#C)̱>gGlN]hsՍU [xOkiBRM6|^7 VWRԃkѿ4_I$֨" T?ಟGoZ>o_7τF( :zx+wZx mXu wZ%- ~WAx\,f)s% ]tڅzq$Jmu#*FQvib0uժT>T̯d_X֌(`(((pG  Ix[g݊xtk_Ze-t߄>.ebw̶V?q ݷ/Y)*AV9 5_9_-kS^#Z"µ&kRŸ>MbL1YV&V5U.ԴJY/-im!%GՏpfw9)oRҋҥ YM&\7xNOvn=0QxM,"-p*\_ّj'ǍOӅ~pu>ؼoq]jz6Q*fռ?t+8!>lz +b?DQx\֟6+!Uc:˾UڎaeBk/( ( ( ( ڟ/cQi:ëY'\k[EnA],-\2Ȋ_c?i{h8.'K(;}- |53Ms_ZKDdRZ=%>"u:^KkQ{iZhͭ}Y4~/+08N:[U]ya74ыON,[ SN+KkYR{[;Rx %XْH]ܯ󽦛M4ӳOF5ѣ?}(EP?I`_M8ߋ?V'u7WOo'Eo8Y囟?<Q_EPEPEP_DJWue"P~)_C|O_?ſJ7'+ Ri)EWKQ@Q@_p7g\|[.u/߲ռ{Eeͼ<1 neӴ5ėMָ'A AW.sG$2dxJ:*He _q~^Ok9wi_u9' $eQ[PK@rx?RQ'>IEӯxN;$M`!}9.lm)iB)SHԩxx7(P(v!ۣV6MQ[ɳB(Т((((/'7{oz}ywucq]|Wq? Uv\,0Ur0U:jqRIԦ*tR*n^NW'^>%5(Ii(oAm]B>"Z|"éGo7v'e eO"xc+4_}R>!P`O A=9E ) A =k AuHH`s#±AX\k2xwLAH|+mF*\8?Ju1<%FYa 4'ž#N*N++э, )4xӚrS)SQ +axJNi_M,ix4v<  ӒxVvgR9fa,~%Z[=}UۻAz%ݮc:Ε$y>%n &3xeyD\5U[^/:M/̀!-jEi$> 1/ea`ڿ&&o 4[&\f֧5??-߶WϨ)6h3i:e ։z+l6A|Ԃ~@`mP9';UsJqeiFNIjt=xbtXypNIL:+mc=kߴE.(i^Pj $+Z&k[ᧈWcw7.B[KJ4I漂 =Po3t<KbJ8l]ޯEζaç*%n&5揨nO2͓W"S?οkg7?/<Zğv|[_sU<3jX3ͤ>$ŝp^O]x!¹ ytfiu*4*BsJ*-i(U䩣n YǸ6Lf `1 F*9ťJ1S-B%&EWQ@Q@Q@&MW[ʿz^?2o_s߆UC)j? ;7QE|!EP__X/FWdK2ҿIkk (?xFZWR2OÜ/=C(I`((((+)e1GTĺN*1 GR8 %UdVy?&ί(OB((((+aju*WW_ɰ?\A5:+7ygfX#׌'QEEPEPEP_؏O#G`/?_v?n?|m_8/JlXAğ}Q_QEQEQEQEQEWYɓVL":L'e}px[/Q=N )=Q_ QEQEQEQE\_i_ɯ_IC_?i_ɯ_IC_ '9|UxCk_1X(ࢊ(((((Jmo8??wNʳ )) Z:EؖP?9#EKQTQE]Q@Q@Q@*Q)W@YɌƟj߳ ug&3٫~Ͽ'_Y47Rj/<'PP (((cii^XW1$VQ<9a'xՒDfVR&ul?} |K׬|.nw| J! .[Bq\0HvZoٳwCi^׿<]s4isΕK.LR=!Tu =NMR|3 dz*K+A-)A+ ,rx2D\T1 Ro}M=Q_gEPEPEP@89G"(4?75ڮ|K5e.|[Xəɸj`M֪51K$R~WO~?jy>u Z7įZF$/I.d$8bSs-8ra1VmIZ?W]!C8h(C,VRBSww0B2*Y7l(@(g$I]dڿş+x:+q'_7uCj7a,|Lo (Т((("+:oοS?E'%xUؓm4+?Š((0bK hWZ.|Ba>fTyj9Wޥjb>qYn3 מOMtR9NJqd[O*)bhקkS:iI=OTIF~?e> @þ>yO֧{-B >藴#4m5o۾q;((((((+?[SJmo8??wQg%|Hn_azQ_GEPEPEPJG:JU>~c?u|ɌƟj߳ uhg6?cԚ `?(8 ( ( ^~ck|cNo>˦ݷȼ(2Í𺶴ާb~'=úkz߆q/{/; FOgoiw;ML! GοHNOq%^Wx dJ. V5se哕ҤbΌATQE$Q@?V'u7WOo'~,[ğq_?묟Wѿd_n~SgǓ0dTQEOQ@Q@Q@~)_C|O_uO~_R/ =|+O?ĞO#l8/IQ_.QEQEQEf<={]Zbc|kѴpuUŖV%esXRxo5ҵO @Wg |' ý*״i]FIT.3Rx aj`Z5|5)J¤M8:_7KWuxڭΉo OLtmRѶk{gr" K y![yN*’kwoͤi50,gzl-_E<I.t+_k*j hOx[Yf}h"^ "#*Sҧij\XC>%q( 4yMZ\`g+}g_q#l8IO CM@(󎐢((( ?fV_?h]&h߇0]$XI"|*E|}bWIJm{ .v2uq Z[8A1nLʆmţT3˩ԟ>'%W'wyraj`ݞ+[I=N4lsLRziVuRORW(V>H(((+ n?joP߷oQ'i 8i|({ OPdyw6߃nPw]x|'x<=O jq ֚ޏzYIkmB`.Jc#x|M,7+r8xJZX|-{k L)V^tߕ㧖8LZ5 KKHks]]-ףWF E ZH;tAp^Qi*ҧZV E¥:Sqdd4vR7^u#w7:Ɨ -3xcK -g-MEouhH礂8 }# BZ(d]p~no'񿁴[Y<NRҙeӴI.G7ub?ӄhkNSIF3-.i+'F͈ǝͅꟘg9r9(yKZz_vզY{UJ?ފ_o_??7ڿè|/?#ON)%Mֹ^rcHRGUJ˳<7Sex6?Y^# ZKD\,tN\g N*p*ua(Iy$QdM+((((((((((2o_s߆UCɓ|zV2OWP?SIܧ%@+ ( 2m"^#іK__X/FWdK2ҽy~W3QEWH3Q@Q@Q@Q@A_K/a?>%qW,?>(__?Ho,r&O863uQE~ ~QEQEQEQE)_ue\SR:Ma _ܞɻ?35w%'a?( ( ( ( ?n?|wW#q ]̼coĿwQSe$袊 ?(((((:L'eQ_d?紟U+,1\+w6oL 袊@O瀢((((M?M~O߫M?M~O߫_8?p7X/ԺEWQ@Q@Q@Q@Q@gRSkAӼux?Q$SUOm-x~Ɵx~$<*ZމROcڥ߈-V: @̊x|ܳ?Y /S(:u1تJu*,mrBuSʜSnɻXpV]_(\jVc*.i*qJ+ݏvL'Rξ$J: 枿I?>mB?S?T3i'Rξ$l_)9w4>mB?S?T3i'Rξ$l_)9w4>mB?S?T3i'Rξ$l_)9w4>mB?^?~Ó_g_??ҏ"(Ꮎ$pG7z?Hc+ʏ`?cO5oU?::>eh>/Oc^)ѼGχ>5*+;I t;YFye8J3BqjQe(6&iM;DI,=M48z=S ((((Ws߅.xĖD)^Bխtk , R8'?>1S3^%Yֿv$5rI{#ui gIXH]>?.w'G<3sZh4I|#iꚶ0R|=kr̆' Upg_a+N*lMf+Wc2R|-yR(ӕJx˖ RVT\Jr+G7z?T3il_)9w4c+ʏ:+3J: 枏r+G7z?Hc+ʏ:+3J: 枏r+G7z?Hc+ʏ:+3J: 枏r+G7z?Hc+ʏ:+3J: 枏r+G7z?Hc+ʏ; sd~f {REмΫ=;6!ŢE۲Ѳ@ܴ<\e~51F7)1X|U*Xҩ<=JYiT8ϓwT1+`,+"J2(ZT'Ԍ[8W\ԥ(g$I]dڿ6hݕy7NkoO2y$Qw;vU5k?V֖Vݱ #w~܂ă%Ko9IG3|*xdWY; u=i9=9i_K) Q{Oa| .^nYrZŪ+!ѭ[Q[֭~+y+xkg4`'?ʏ+!ѭ[Q[֭~^x/Y!П4 W*? Fm~GCnZ?ңy+xkg4yB|1_^h+wշjwJ>e9 O zS?E'U{kV{gzU#ooٳ_ 5k_ž"_u|5p4AյwyZ~u0<~3 G q Sիj4hrjիB*tsJaE9JMF)ߕ<.S)̡N?9xLaGNR%)IMcȢ+ ( ( ( ( ( ()jZnX^iZj6_څ77w176v $6<FK2:?tajM__ cfgeemw\.kMIȶ6tg&kϿrN"8s3xzR#5,>" ^H_^[8R8-L5NpowNJr9EXPّMg@umEŦ/|ĚYf/7V~;¦KovlY|%V4]cڝ:iZj:VcsVP^Y^E ͵M $xe6g?cO[_M3sko6 |ae3GldW=((Q\>*Xk U0զ*8.>1 Qy^6xwT1Qԯ5V_ޅyyoE~?|A7?g^s!Үn-+9h=#wWiksf0 p?O۳uy8iqPk\$I^|-mp @6jnɲLnOjR`(+yIݒNN6&܌ +~߶y#g⥐:7WqcmGGU?i߲4+Iv~'5ctǍ^&M9 _*ZfX}_/־ΖEƛGm.|2[?oO}Om~i?Sm%6qr?wkKkѫ7rN.tBdyX,p $K#h@PO?%mqŽR'|V[{.7=΃ FGΗ^!Ȏ4`>%?Ʊ>.ծװ#Y.'n<䙮a5e˨RչvA> cRaQ\LRXx_myɾ &ٿï+i6t%_ᩭ[kjgn/ʘIfѾ)Z@5Ma)I("^ճ?<9]̂R5 nNR=-~ixx(er̒a7q>pK< Eo C]ϿO%o@x*g_w7T&x'V0?V+!0u{?GC{La>< Eo C]ϿO%o@ GR8R?oK~?|dR$x[\]c_ Jӯ%2j݄.(y?W9s*qY>c = 8xP2*R)J1RQ]%8XX5|-I*Fzr9AᰱSQM2vQ_nQEQEQEQE)_ue\SR ~ѿ<;xx4 AoxVJh.uyS{O'xæ+' ~Q_? 3ï; ?*g_wAo+xOZ}B| +S?|:ýO!0u{?GD' ~Q_? 3ï; ?*g_wAo+xOZ}B| +b?i?o੟L>O'U4j'P_~Ҟ߆(i_ |"t?5.KNBbk L~}iY-, Ps 5j]<ZJJJEy.o q(S!ԫWV8s`4(]&՟ҭQ_EPEPEPEPEP_˿e&O{I[2d~og|Ro~>,ִ#дǚٺj𦥪֦8ս0Ʋ:dž6ı15С?¬U(nҼW<'VCңNZBU*MH;FNRvM&?r]Tϼo?m(Tϼo?m+o?*8wyo4cg*̿ʏ*+wwS> wS> o?*8wyo46qBq_WU?3OJ?U?3OJ?Hcg*̿ʏ*+wwS> wS> o?*8wyo46qBq_WU?3OJ?U?3OJ?Hcg*̿ʏ_4K/d!77cJ׾^5/t k}CJ׵B[+C ݃_8aٶ+c(e%zXppj398N2ddvi [:85hULS*JTUe(MFK-5uiQE!EPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPEPY6XVMzgH.b'N7!EiM;}Z&Vi4OTGϾ+?d/e:xYĿ>99$~f$I$'A~^Bf1$Gk F>Q_k™fʚqQ5(-^fL/ܾ{|׶/ٟqT8~|3#|/J!vU?Ig2]>;| \ < .xAl4Q_b3 z&^ؚ˧ϐY/aFɫ/e -z{ c/PVPuO¸icj hvmv闺zM ? ,ĶGj(x7bࣙNNcq)=U|pͥt);km=4= c0ে)4OҞ3Xp2u#{iiuC[YAmc8a#AWb+ׯZV?rg T!F?JEЪu@?-V%Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@Q@E Dd D  3 A?"`b e+_7YZ n e+_7YZPNG  IHDRd54gAMAPLTEPАPPPPPPPPPPPPАPААААPААPPPPPPPPPАPААPАPPPАPPPPPАPАPPPPPPPPPPPАPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPPАPPPPPPPPPPPPАPPPPPPPPPPP՚ݮTiX%c9q59;?CKitRNSS% pHYs.>IDATxX {: mG| C}I@E=7n&9''UM PB+R9IХqƱ[Mç.ZOi+5i]W{XU5ib NxS~R%6;֪2(ߊ&E*}و$ڲմ?Ԙ:diy.˭$Zع$/,jҋE^35׈Ţ>")۞ݐĵP<"btz8nܱB>0.~1;d,i "5q_kΑ"Բ۶n}nM=!R2WV XV.'<[:ELukEAC~= Y!莦wZI)~=C÷a[nyC$@ 4_+}*!q+Jev5 |I ts?HoN@A}_e,?XYZ:kl~+( J | ! " ~  W n{800000000000000 0 00000 0 000000 0 0 0 00000000 0 0 000 0 0000000 0 0 0000000 0 0 000 0 000000 0 0 0: J W n{8K00V@0@0@0j00j00j00@0j00K00K00x#K00K00K00K00K00K00K00@0K00 ~K00 K00 K00K00K00<K00K00K002K00K00 K00 K00K00 K00 K00K00K00K00K00 K00I0(I0(K00    X : +({8@0(  B S  ?S l$T k$U ̈$_*urn:schemas-microsoft-com:office:smarttagscountry-regionhttp://www.5iantlavalamp.com/h*urn:schemas-microsoft-com:office:smarttagsCity0http://www.5iamas-microsoft-com:office:smarttagsV*urn:schemas-microsoft-com:office:smarttagsplacehttp://www.5iantlavalamp.com/  =Eklw}/4' I ! i l   W a c 8FH =G/6| . / ;333333  "Zg ozrqk ,X>9B2tQ*U jP[H m&IPJFqF{q^`56OJPJQJ^Jo(-q^`OJQJ^Jo(hHoqkk^k`OJQJo(hHq; ; ^; `OJQJo(hHq  ^ `OJQJ^Jo(hHoq^`OJQJo(hHq^`OJQJo(hHq{{^{`OJQJ^Jo(hHoqKK^K`OJQJo(hH^`OJPJQJ^Jo(-  ^ `OJQJ^Jo(hHott^t`OJQJo(hHDD^D`OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoTT^T`OJQJo(hHq^`56OJPJQJ^Jo(-q^`OJQJ^Jo(hHoqpp^p`OJQJo(hHq@ @ ^@ `OJQJo(hHq^`OJQJ^Jo(hHoq^`OJQJo(hHq^`OJQJo(hHq^`OJQJ^Jo(hHoqPP^P`OJQJo(hHq^`56OJPJQJ^Jo(-  ^ `OJQJ^Jo(hHoyy^y`OJQJo(hHII^I`OJQJo(hH^`OJQJ^Jo(hHo^`OJQJo(hH^`OJQJo(hH^`OJQJ^Jo(hHoYY^Y`OJQJo(hHq#^`56OJPJQJ^Jo(hH-q^`OJQJ^Jo(hHoqkk^k`OJQJo(hHq; ; ^; `OJQJo(hHq  ^ `OJQJ^Jo(hHoq^`OJQJo(hHq^`OJQJo(hHq{{^{`OJQJ^Jo(hHoqKK^K`OJQJo(hHl@@^@`OJPJQJ^Jo(-l  ^ `OJQJ^Jo(hHol^`OJQJo(hHl^`OJQJo(hHl||^|`OJQJ^Jo(hHolLL^L`OJQJo(hHl^`OJQJo(hHl^`OJQJ^Jo(hHol  ^ `OJQJo(hH>9BJFqU jH mrqk tQn+        d         n+        n+        n+        d         k^1H;:lL\T q gd_eJ.$t$5X1u@~rF~NGKQ[fX{Y-k^g` d?fUit#uxr_|<~e =]Qyf\6jkAg~%H[| WL{tw;iR{MF,]P$o$u2  !?XY 333333W33@A@UnknownGz Times New Roman5Symbol3& z Arial?5 z Courier New;Wingdings"1hF1FL"YSd24d 2qHP)?W22Perspectives on Nucleic Acid Chemistry for Therapykuleuvenkuleuven$      Oh+'0( <H h t  4Perspectives on Nucleic Acid Chemistry for Therapy kuleuven Normal.dot kuleuven24Microsoft Office Word@x@<^@2#>@̈՜.+,0 hp|   3Perspectives on Nucleic Acid Chemistry for Therapy Title  !"#$%&'()*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~Root Entry FpẅData 1TableA3WordDocument?:SummaryInformation(DocumentSummaryInformation8CompObjq  FMicrosoft Office Word Document MSWordDocWord.Document.89q