The next early career academics presenting in the Peptide and Protein Science online series will be Nicholas Mitchell from the University of Nottingham and Anna Barnard from Imperial College London.
Nicholas Mitchell 鈥� University of Nottingham
Title: A Radical Approach to Peptide and Protein Modification
Abstract: Chemistry that enables the site-selective modification of peptides and proteins facilitates the preparation of therapeutic agents and tools to interrogate biochemical pathways. Among the numerous bioconjugation techniques developed to install groups of interest, those that generate carbon-carbon bonds are significantly underrepresented despite affording proteolytically stable, biogenic linkages that effectively mimic natural modifications. We are exploring the interception of free-radical-mediated cysteine desulfurisation to enable peptide cyclisation and the installation of post-translational modifications (PTMs), PTM mimics, and non-standard sidechains into peptide and protein scaffolds via C(sp3)-C(sp3) and C(sp3)-C(sp2) bond formation.
Anna Barnard 鈥� Imperial College London
Title: Innovative Approaches to Targeting Protein-Protein Interactions
Abstract: Protein-protein interactions are a ubiquitous feature of biological systems and are commonly responsible for disease pathways and the survival of pathogenic organisms. In this presentation, I will discuss our work developing peptide mimics of a key protein-protein interaction in bacteria with the aim of preventing the formation of bacterial persisters - dormant phenotypic variants capable of surviving antibiotic treatment and our approaches to the design of photoswitchable stapled peptides with an unexpected mode of action.
For upcoming series, please visit the RSC PPSG website
If you would like to present in future seminars, please contact one of the organisers/committee.
Louis Luk
Chris Coxon
Louise Walport
We always welcome new members to join the RSC PPSG group, from early to established career researchers. If you are interested, please contact the chair:
Alethea Tabor: a.b.tabor@ucl.ac.uk
Nicholas Mitchell 鈥� University of Nottingham
Title: A Radical Approach to Peptide and Protein Modification
Abstract: Chemistry that enables the site-selective modification of peptides and proteins facilitates the preparation of therapeutic agents and tools to interrogate biochemical pathways. Among the numerous bioconjugation techniques developed to install groups of interest, those that generate carbon-carbon bonds are significantly underrepresented despite affording proteolytically stable, biogenic linkages that effectively mimic natural modifications. We are exploring the interception of free-radical-mediated cysteine desulfurisation to enable peptide cyclisation and the installation of post-translational modifications (PTMs), PTM mimics, and non-standard sidechains into peptide and protein scaffolds via C(sp3)-C(sp3) and C(sp3)-C(sp2) bond formation.
Anna Barnard 鈥� Imperial College London
Title: Innovative Approaches to Targeting Protein-Protein Interactions
Abstract: Protein-protein interactions are a ubiquitous feature of biological systems and are commonly responsible for disease pathways and the survival of pathogenic organisms. In this presentation, I will discuss our work developing peptide mimics of a key protein-protein interaction in bacteria with the aim of preventing the formation of bacterial persisters - dormant phenotypic variants capable of surviving antibiotic treatment and our approaches to the design of photoswitchable stapled peptides with an unexpected mode of action.
For upcoming series, please visit the RSC PPSG website
If you would like to present in future seminars, please contact one of the organisers/committee.
Louis Luk
Chris Coxon
Louise Walport
We always welcome new members to join the RSC PPSG group, from early to established career researchers. If you are interested, please contact the chair:
Alethea Tabor: a.b.tabor@ucl.ac.uk
